https://doi.org/10.36106/paripex/8501801
Journal: PARIPEX INDIAN JOURNAL OF RESEARCH, 2022, p.45-47
Publisher: World Wide Journals
Authors: Sandeep Chandrakar, Rajendra Ratre, Nitish Kumar Rai, T Narasimha Murty
Abstract
INTRODUCTION : H. pylori is a gastric pathogen that colonizes approximately 50%-60% of the world's population. Infection with H. pylori causes chronic inflammation and significantly increases the risk of developing duodenal, gastric ulcer disease and gastric carcinoma. This study is undertaken to determine the clinical and pathological profile of gastric carcinoma in our institute and to find out the prevalence of H. pylori infection in gastric carcinoma patients. MATERIALS AND METHODS :We conducted our study in the Department of Surgery, Dr. B. R. A. M. Hospital, Raipur, C.G. over a period of 18 months. It was a hospital based, cross-sectional observational study. During upper GI endoscopy, site of the lesion and macroscopic type of the lesions were identified and recorded. Multiple tissue biopsy samples (>10) were collected from non-necrosed region of cancer. One piece of each paired specimen were immediately subjected to RapidUrease Test dry kit (RUT) for detection of Helicobacter pylori. Further these biopsy specimens were subjected to modified giemsa staining and culture. RESULTS : Out of the 70 cases of gastric carcinoma, the prevalence of H.pylori was 64.28% . The most common age group associated with gastric carcinoma with H.pylori infection was more than 60 years. There was male predominance seen for both gastric carcinoma and gastric carcinoma positive for H.pylori infection. The most common lesion for gastric carcinoma and those positive for H.pylori was ulceroproliferative type. The most common site of stomach involved in cases of Gastric carcinoma associated with H.pylori infection was antrum+pylorus of stomach. The most common histological type of gastric carcinoma associated with H.pylori infection was poorly differentiated adenocarcinoma CONCLUSION : On the basis of our study it is evident that H.pylori is an independent risk factor for gastric carcinoma. .Infection with H. pylori causes chronic inflammation and significantly increases the risk of developing duodenal, gastric ulcer disease and gastric carcinoma.
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About this publication
| Number of citations | 0 |
| Number of works in the list of references | 18 |
| Journal indexed in Scopus | No |
| Journal indexed in Web of Science | No |
